Design, synthesis and biological evaluation of alantolactone derivatives as potential anti-inflammatory agents

While screening for potential anti-inflammatory natural product scaffolds, alantolactone (1) was found to attenuate LPS-induced pro-inflammatory mediators in RAW264.7 macrophage cells. In this regard, a series of 17 novel thiol derivatives of1 has been synthesized and evaluated as inhibitors of pro-...

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Bibliographic Details
Published in:Medicinal Chemistry Research, Vol. 28, No. 6 (2019), p. 849-856
Main Author: Kumar, Chetan (Author)
Other Involved Persons: Kumar, Anil ; Nalli, Yedukondalu ; Lone, I. ; Satti, K. ; Verma, K. ; Ahmed, Zabeer ; Ali, Asif
Format: electronic Article
Physical Description:Online-Ressource
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