Design, synthesis and biological evaluation of alantolactone derivatives as potential anti-inflammatory agents
While screening for potential anti-inflammatory natural product scaffolds, alantolactone (1) was found to attenuate LPS-induced pro-inflammatory mediators in RAW264.7 macrophage cells. In this regard, a series of 17 novel thiol derivatives of1 has been synthesized and evaluated as inhibitors of pro-...
|Published in:||Medicinal Chemistry Research, Vol. 28, No. 6 (2019), p. 849-856|
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