SIRT1 overexpression in skeletal muscle in vivo induces increased insulin sensitivity and enhanced complex I but not complex II–V functions in individual subsarcolemmal and intermyofibrillar mitochondria

SIRT1 is known to improve insulin resistance (IR), but whether this effect is direct or not is still unclear, and this question has not been addressed in vivo in the skeletal muscle. Therefore, we sought to test if acute overexpression of SIRT1 in skeletal muscle of high-fat diet (HFD) rats in vivo...

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Bibliographic Details
Published in:Journal of physiology and biochemistry, Vol. 71, No. 2 (2015), p. 177-190
Main Author: Zhang, Hao-Hao
Other Involved Persons: Qin, Gui-Jun ; Li, Xia-Lian ; Zhang, Ying-Hui ; Du, Pei-Jie ; Zhang, Peng-Yu ; Zhao, Yan-Yan ; Wu, Jing
Format: electronic Article
Language:English
ISSN:1877-8755
Physical Description:Online-Ressource
DOI:10.1007/s13105-015-0396-x
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