Experimental filariasis of Dipetalonema dessetae | in Proechimys oris: | 3. Effects of parasitism on the pharmacokinetics of diethylcarbamazine
The pharmacokinetic parameters of diethylcarbamazine were compared in the plasma and peritoneal fluid of 5 non-infected rodents. In the filarial animals, the absorption rate constant and the elimination rate constant were significantly increased. The peak plasma concentration was twofold higher in t...
|Published in:||European Journal of Drug Metabolism and Pharmacokinetics, Vol. 8, No. 4 (1983), p. 313-320|
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