Gene expression profiling of liver cells after copper overload in vivo and in vitro reveals new copper-regulated genes

Copper toxicity in the liver is mediated by free-radical generation, resulting in oxidative stress. To prevent toxic accumulation of copper, liver cells adapt to high copper levels. Here, we used microarray analysis to compare the adaptive responses on global gene expression in liver cells exposed t...

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Bibliographic Details
Published in:JBIC Journal of Biological Inorganic Chemistry, Vol. 12, No. 4 (2007), p. 495-507
Main Author: Muller, Patricia
Other Involved Persons: Bakel, Harm ; Sluis, Bart ; Holstege, Frank ; Wijmenga, Cisca ; Klomp, J.
Format: electronic Article
Language:English
ISSN:1432-1327
Item Description:The online version of this article (doi:10.1007/s00775-006-0201-y) contains supplementary material, which is available to authorized users. Cisca Wijmenga and Leo W. J. Klomp contributed equally.
Physical Description:Online-Ressource
DOI:10.1007/s00775-006-0201-y
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