Influence of the SLCO1B1*1b | and *5 | haplotypes on pravastatin’s cholesterol lowering capabilities and basal sterol serum levels

We previously showed that variant SLCO1B1 haplotype*1b(A388G) accelerates and that*5(T521C) delays hepatocellular uptake of the HMG-CoA reductase inhibitor pravastatin [Mwinyi et al. (2004): Clin Pharmacol Ther 75:415–421]. In the present study we checked for differential effects of variant SLCO1B1...

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Bibliographic Details
Published in:Naunyn-Schmiedeberg's Archives of Pharmacology, Vol. 373, No. 1 (2006), p. 45-50
Main Author: Gerloff, Thomas
Other Involved Persons: Schaefer, Melanie ; Mwinyi, Jessica ; Johne, Andreas ; Sudhop, Thomas ; Lütjohann, Dieter ; Roots, Ivar ; Bergmann, Klaus
Format: electronic Article
Language:English
ISSN:1432-1912
Physical Description:Online-Ressource
DOI:10.1007/s00210-006-0053-6
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