Immune-orthogonal orthologues of AAV capsids and of Cas9 circumvent the immune response to the administration of gene therapy

Protein-based therapeutics can activate the adaptive immune system, leading to the production of neutralizing antibodies and the clearance of the treated cells mediated by cytotoxic T cells. Here, we show that the sequential use of immune-orthogonal orthologues of CRISPR-associated protein 9 (Cas9)...

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Bibliographic Details
Published in:Nature biomedical engineering, (07.2019)
Main Author: Moreno, Ana M
Other Involved Persons: Palmer, Nathan ; Alemán, Fernando ; Chen, Genghao ; Pla, Andrew ; Jiang, Ning ; Leong Chew, Wei ; Law, Mansun ; Mali, Prashant
Format: electronic Article
Language:English
ISSN:2157-846X
Item Description:Date Revised 03.10.2019
published: Print-Electronic
ErratumIn: Nat Biomed Eng. 2019 Aug 27;:. - PMID 31455920
Citation Status Publisher
Copyright: From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Physical Description:Online-Ressource
DOI:10.1038/s41551-019-0431-2
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