Cholesterol 24-Hydroxylation by CYP46A1 : Benefits of Modulation for Brain Diseases

Cholesterol 24-hydroxylation is the major mechanism for cholesterol removal from the brain and the reaction catalyzed by cytochrome P450 46A1 (CYP46A1), a CNS-specific enzyme. This review describes CYP46A1 in the context of cholesterol homeostasis in the brain and summarizes available experimental d...

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Bibliographic Details
Published in:Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics, Vol. 16, No. 3 (2019), p. 635-648
Main Author: Petrov, Alexey M
Other Involved Persons: Pikuleva, Irina A
Format: electronic Article
Language:English
ISSN:1878-7479
Item Description:Date Revised 08.10.2019
published: Print
Citation Status In-Data-Review
Copyright: From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Physical Description:Online-Ressource
DOI:10.1007/s13311-019-00731-6
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