In vivo RNA editing of point mutations via RNA-guided adenosine deaminases

We present in vivo sequence-specific RNA base editing via adenosine deaminases acting on RNA (ADAR) enzymes with associated ADAR guide RNAs (adRNAs). To achieve this, we systematically engineered adRNAs to harness ADARs, and comprehensively evaluated the specificity and activity of the toolsets in v...

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Bibliographic Details
Published in:Nature methods, Vol. 16, No. 3 (2019), p. 239-242
Main Author: Katrekar, Dhruva
Other Involved Persons: Chen, Genghao ; Meluzzi, Dario ; Ganesh, Ashwin ; Worlikar, Atharv ; Shih, Yu-Ru ; Varghese, Shyni ; Mali, Prashant
Format: electronic Article
Language:English
ISSN:1548-7105
Item Description:Date Completed 22.05.2019
Date Revised 08.08.2019
published: Print-Electronic
CommentIn: Nat Methods. 2019 Mar;16(3):209. - PMID 30814692
Citation Status MEDLINE
Copyright: From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Physical Description:Online-Ressource
DOI:10.1038/s41592-019-0323-0
Subjects:
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