A Novel Function for 15-Lipoxygenases in Cholesterol Homeostasis and CCL17 Production in Human Macrophages

Arachidonate 15-lipoxygenase (ALOX15) and arachidonate 15-lipoxygenase, type B (ALOX15B) catalyze the dioxygenation of polyunsaturated fatty acids and are upregulated in human alternatively activated macrophages (AAMs) induced by Th2 cytokine interleukin-4 (IL-4) and/or interleukin-13. Known primari...

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Bibliographic Details
Published in:Frontiers in immunology, Vol. 9 (2018), p. 1906
Main Author: Snodgrass, Ryan G
Other Involved Persons: Zezina, Ekaterina ; Namgaladze, Dmitry ; Gupta, Sahil ; Angioni, Carlo ; Geisslinger, Gerd ; Lütjohann, Dieter ; Brüne, Bernhard
Format: electronic Article
Language:English
ISSN:1664-3224
Item Description:Date Completed 30.09.2019
Date Revised 30.09.2019
published: Electronic-eCollection
Citation Status MEDLINE
Copyright: From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Physical Description:Online-Ressource
DOI:10.3389/fimmu.2018.01906
Subjects:
Journal Article
Research Support, Non-U.S. Gov't
Arachidonate 15-Lipoxygenase > genetics > *metabolism
Cell Movement > genetics
Chemokine CCL17 > *biosynthesis
Cholesterol > *metabolism
Cytokines > genetics > metabolism
Gene Expression
*Homeostasis
Humans
Lipid Metabolism
Macrophages > *immunology > *metabolism
Protein Binding
RNA, Small Interfering > genetics
Serum Response Element
Sterol Regulatory Element Binding Protein 2 > metabolism
arachidonate 15-lipoxygenase
chemokine
cholesterol
interleukin-4
lipoxygenase
macrophage
sterol regulatory element binding protein-2
type B
Chemokine CCL17
Cytokines
RNA, Small Interfering
SREBF2 protein, human
Sterol Regulatory Element Binding Protein 2
Cholesterol
97C5T2UQ7J
Arachidonate 15-Lipoxygenase
EC 1.13.11.33
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Published in:
Frontiers in immunology, Vol. 9 (2018), p. 1906
Further Information:
http://dx.doi.org/10.3389/fimmu.2018.01906
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