Cross-ancestry genome-wide association analysis of corneal thickness strengthens link between complex and Mendelian eye diseases

Central corneal thickness (CCT) is a highly heritable trait associated with complex eye diseases such as keratoconus and glaucoma. We perform a genome-wide association meta-analysis of CCT and identify 19 novel regions. In addition to adding support for known connective tissue-related pathways, path...

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Bibliographic Details
Published in:Nature communications, Vol. 9, No. 1 (2018), p. 1864
Main Author: Iglesias, Adriana I
Other Involved Persons: Mishra, Aniket ; Vitart, Veronique ; Bykhovskaya, Yelena ; Höhn, René ; Springelkamp, Henriët ; Cuellar-Partida, Gabriel ; Gharahkhani, Puya ; Bailey, Jessica N Cooke ; Willoughby, Colin E ; Li, Xiaohui ; Yazar, Seyhan ; Nag, Abhishek ; Khawaja, Anthony P ; Polašek, Ozren ; Siscovick, David ; Mitchell, Paul ; Tham, Yih Chung ; Haines, Jonathan L ; Kearns, Lisa S ; Hayward, Caroline ; Shi, Yuan ; van Leeuwen, Elisabeth M ; Taylor, Kent D ; Blue Mountains Eye Study—GWAS group ; Bonnemaijer, Pieter ; Rotter, Jerome I ; Martin, Nicholas G ; Zeller, Tanja ; Mills, Richard A ; Souzeau, Emmanuelle ; Staffieri, Sandra E ; Jonas, Jost B ; Schmidtmann, Irene ; Boutin, Thibaud ; Kang, Jae H ; Lucas, Sionne E M ; Wong, Tien Yin ; Beutel, Manfred E ; Wilson, James F ; NEIGHBORHOOD Consortium ; Wellcome Trust Case Control Consortium 2 (WTCCC2) ; Uitterlinden, André G ; Vithana, Eranga N ; Foster, Paul J ; Hysi, Pirro G ; Hewitt, Alex W ; Khor, Chiea Chuen ; Pasquale, Louis R ; Montgomery, Grant W ; Klaver, Caroline C W ; Aung, Tin ; Pfeiffer, Norbert ; Mackey, David A ; Hammond, Christopher J ; Cheng, Ching-Yu ; Craig, Jamie E ; Rabinowitz, Yaron S ; Wiggs, Janey L ; Burdon, Kathryn P ; van Duijn, Cornelia M ; MacGregor, Stuart ; Wang, Jie Jin ; Rochtchina, Elena ; Attia, John ; Scott, Rodney ; Holliday, Elizabeth G ; Baird, Paul N ; Xie, Jing ; Inouye, Michael ; Viswanathan, Ananth ; Sim, Xueling ; Allingham, R Rand ; Brilliant, Murray H ; Budenz, Donald L ; Christen, William G ; Fingert, John ; Friedman, David S ; Gaasterland, Douglas ; Gaasterland, Terry ; Hauser, Michael A ; Kraft, Peter ; Lee, Richard K ; Lichter, Paul R ; Liu, Yutao ; Loomis, Stephanie J ; Moroi, Sayoko E ; Pericak-Vance, Margaret A ; Realini, Anthony ; Richards, Julia E ; Schuman, Joel S ; Scott, William K ; Singh, Kuldev ; Sit, Arthur J ; Vollrath, Douglas ; Weinreb, Robert N ; Wollstein, Gadi ; Zack, Donald J ; Zhang, Kang ; Donnelly, Peter ; Barroso, Ines ; Blackwell, Jenefer M ; Bramon, Elvira ; Brown, Matthew A ; Casas, Juan P ; Corvin, Aiden ; Deloukas, Panos ; Duncanson, Audrey ; Jankowski, Janusz ; Markus, Hugh S ; Mathew, Christopher G ; Palmer, Colin N A ; Plomin, Robert ; Rautanen, Anna ; Sawcer, Stephen J ; Trembath, Richard C ; Wood, Nicholas W ; Spencer, Chris C A ; Band, Gavin ; Bellenguez, Céline ; Freeman, Colin ; Hellenthal, Garrett ; Giannoulatou, Eleni ; Pirinen, Matti ; Pearson, Richard ; Strange, Amy ; Su, Zhan ; Vukcevic, Damjan ; Langford, Cordelia ; Hunt, Sarah E ; Edkins, Sarah ; Gwilliam, Rhian ; Blackburn, Hannah ; Bumpstead, Suzannah J ; Dronov, Serge ; Gillman, Matthew ; Gray, Emma ; Hammond, Naomi ; Jayakumar, Alagurevathi ; McCann, Owen T ; Liddle, Jennifer ; Potter, Simon C ; Ravindrarajah, Radhi ; Ricketts, Michelle ; Waller, Matthew ; Weston, Paul ; Widaa, Sara ; Whittaker, Pamela
Format: electronic Article
Language:English
ISSN:2041-1723
Item Description:Date Completed 27.11.2018
Date Revised 08.05.2019
published: Electronic
ErratumIn: Nat Commun. 2019 Jan 8;10(1):155. - PMID 30622277
Citation Status MEDLINE
Copyright: From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Physical Description:Online-Ressource
DOI:10.1038/s41467-018-03646-6
Subjects:
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