High Prevalence of Abacavir-associated L74V/I Mutations in Kenyan Children Failing Antiretroviral Therapy

A survey of 461 HIV-infected Kenyan children receiving antiretroviral therapy found 143 (31%) failing virologically. Drug resistance mutations were found in 121; 37 had L74V/I mutations, with 95% receiving abacavir (ABC)-containing regimens. L74V/I was associated with current ABC usage (P = 0.0001)....

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Bibliographic Details
Published in:The Pediatric infectious disease journal, Vol. 36, No. 8 (2017), p. 758-760
Main Author: Dziuban, Eric J
Other Involved Persons: DeVos, Joshua ; Ngeno, Bernadette ; Ngugi, Evelyn ; Zhang, Guoqing ; Sabatier, Jennifer ; Wagar, Nick ; Diallo, Karidia ; Nganga, Lucy ; Katana, Abraham ; Yang, Chunfu ; Rivadeneira, Emilia D ; Mukui, Irene ; Odhiambo, Francesca ; Redfield, Robert ; Raizes, Elliot
Format: electronic Article
Language:English
ISSN:1532-0987
Item Description:Date Completed 18.09.2017
Date Revised 08.03.2019
published: Print
Citation Status MEDLINE
Copyright: From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Physical Description:Online-Ressource
DOI:10.1097/INF.0000000000001597
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