Estimation of the frequency of inherited germline mutations by whole exome sequencing in ethyl nitrosourea-treated and untreated gpt delta mice

BACKGROUND: Germline mutations are heritable and may cause health disadvantages in the next generation. To investigate trans-generational mutations, we treated male gpt delta mice with N-ethyl-N-nitrosourea (ENU) (85 mg/kg intraperitoneally, weekly on two occasions). The mice were mated with untreat...

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Bibliographic Details
Published in:Genes and environment : the official journal of the Japanese Environmental Mutagen Society, Vol. 38 (2016), p. 10
Main Author: Masumura, Kenichi (Author)
Other Involved Persons: Toyoda-Hokaiwado, Naomi ; Ukai, Akiko ; Gondo, Yoichi ; Honma, Masamitsu ; Nohmi, Takehiko
Format: electronic Article
Language:English
ISSN:1880-7046
Item Description:Date Completed 28.06.2016
Date Revised 11.01.2019
published: Electronic-eCollection
Citation Status PubMed-not-MEDLINE
Copyright: From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Physical Description:Online-Ressource
DOI:10.1186/s41021-016-0035-y
Subjects:
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