Molecular Changes in Opioid Addiction : The Role of Adenylyl Cyclase and cAMP/PKA System

Copyright © 2016. Published by Elsevier Inc.

Bibliographic Details
Published in:Progress in molecular biology and translational science, Vol. 137 (2016), p. 203-27
Main Author: Chan, Patrick
Other Involved Persons: Lutfy, Kabirullah
Format: electronic Article
Language:English
ISSN:1878-0814
Item Description:Date Completed 30.12.2016
Date Revised 31.12.2016
published: Print-Electronic
Citation Status MEDLINE
Copyright: From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Physical Description:Online-Ressource
DOI:10.1016/bs.pmbts.2015.10.005
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Description:
  • Copyright © 2016. Published by Elsevier Inc.
  • For centuries, opiate analgesics have had a considerable presence in the treatment of moderate to severe pain. While effective in providing analgesia, opiates are notorious in exerting many undesirable adverse reactions. The receptor targets and the intracellular effectors of opioids have largely been identified. Furthermore, much of the mechanisms underlying the development of tolerance, dependence, and withdrawal have been delineated. Thus, there is a focus on developing novel compounds or strategies in mitigating or avoiding the development of tolerance, dependence, and withdrawal. This review focuses on the adenylyl cyclase and cyclic adenosine 3,5-monophosphate (cAMP)/protein kinase A (AC/cAMP/PKA) system as the central player in mediating the acute and chronic effects of opioids. This chapter also reviews the neuronal adaptive changes in the locus coeruleus, amygdala, periaqueductal gray, and ventral tegmental area induced by acute and chronic actions of opioid because these neuronal adaptive changes in these regions may underlie the behavioral changes observed in opiate users and abusers