Parathyroid hormone response to two levels of vitamin D deficiency is associated with high risk of medical problems during hospitalization in patients with hip fracture

BACKGROUND: Vitamin D and the parathyroid hormone (PTH) response play an important role in hip fracture patients. This study was carried out to determine the factors associated with the PTH response to different levels of vitamin D deficiency during hospitalization

Bibliographic Details
Published in:Journal of endocrinological investigation, Vol. 38, No. 10 (2015), p. 1129-35
Main Author: Alarcón, T
Other Involved Persons: González-Montalvo, J I ; Hoyos, R ; Diez-Sebastián, J ; Otero, A ; Mauleon, J L
Format: electronic Article
Language:English
ISSN:1720-8386
Item Description:Date Completed 17.06.2016
Date Revised 13.11.2018
published: Print-Electronic
Citation Status MEDLINE
Copyright: From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Physical Description:Online-Ressource
DOI:10.1007/s40618-015-0320-9
Subjects:
QR Code: Show QR Code
LEADER 04537nma a2200865 c 4500
001 NLM249671794
003 DE-601
005 20181229051111.0
007 cr uuu---uuuuu
008 180206s2015 000 0 eng d
024 7 |a 10.1007/s40618-015-0320-9  |2 doi 
028 5 2 |a pubmed19n0832.xml 
035 |a (DE-599)NLM26048596 
040 |b ger  |c GBVCP 
041 0 |a eng 
100 1 |a Alarcón, T 
245 1 0 |a Parathyroid hormone response to two levels of vitamin D deficiency is associated with high risk of medical problems during hospitalization in patients with hip fracture  |h Elektronische Ressource 
300 |a Online-Ressource 
500 |a Date Completed 17.06.2016 
500 |a Date Revised 13.11.2018 
500 |a published: Print-Electronic 
500 |a Citation Status MEDLINE 
500 |a Copyright: From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine 
520 |a BACKGROUND: Vitamin D and the parathyroid hormone (PTH) response play an important role in hip fracture patients. This study was carried out to determine the factors associated with the PTH response to different levels of vitamin D deficiency during hospitalization 
520 |a METHODS: This was a cross-sectional study of patients over 64 years of age admitted with an acute fragility hip fracture between March 1st 2009 and November 30th 2012. Demographic, clinical, functional, and cognitive function were evaluated at admission and during hospitalization. Levels of 25-hydroxyvitamin D (25-OHD) and PTH were analyzed. Two 25-OHD cut-off points were considered, <12 ng/ml and 12-20 ng/ml. Multivariate logistic regression analysis was used 
520 |a RESULTS: Mean age of the 607 patients included was 84.7 years (SD 7.10), and 81.9 % were women. The mean 25-OHD level in the total sample was 13.2 (SD 11.1) ng/ml. Levels of 25-OHD <12 ng/ml were present in 347 patients (57.2 %), of whom 158 (45.5 %) had secondary hyperparathyroidism (SHPT) (PTH >65 pg/ml). 25-OHD levels of 12-20 ng/ml were present in 168 (27.7 %) patients, of whom 47 (28 %) had SHPT. Following logistic regression, SHPT was associated in both groups (25-OHD <12 and 12-20 ng/ml) with a greater number of medical problems during hospitalization. In the 25-OHD group <12 ng/ml, SHPT was also associated with poorer glomerular filtration rates 
520 |a CONCLUSION: The PTH response to vitamin D deficiency in hip fracture patients may be a marker for patients with higher risk of developing multiple medical problems, both when considering severe (<12 ng/ml) and moderate (12-20 ng/ml) vitamin D deficiency 
611 2 7 |a Journal Article  |2 gnd 
611 2 7 |a Research Support, Non-U.S. Gov't  |2 gnd 
653 2 |a Aged  |6 D000368 
653 2 |a Aged, 80 and over  |6 D000369 
653 2 |a Cross-Sectional Studies  |6 D003430 
653 2 |a Female  |6 D005260 
653 2 |a Hip Fractures  |6 D006620  |a *blood  |6 Q000097  |a complications  |6 Q000150 
653 2 |a Humans  |6 D006801 
653 2 |a Male  |6 D008297 
653 2 |a Middle Aged  |6 D008875 
653 2 |a Parathyroid Hormone  |6 D010281  |a *blood  |6 Q000097 
653 2 |a Vitamin D  |6 D014807  |a *analogs & derivatives  |6 Q000031  |a blood  |6 Q000097 
653 2 |a Vitamin D Deficiency  |6 D014808  |a *blood  |6 Q000097  |a complications  |6 Q000150 
655 7 |a Elderly  |2 gnd 
655 7 |a Hip fracture  |2 gnd 
655 7 |a Outcomes  |2 gnd 
655 7 |a Secondary hyperparathyroidism  |2 gnd 
655 7 |a Vitamin D  |2 gnd 
655 7 |a Parathyroid Hormone  |2 gnd 
655 7 |a Vitamin D  |2 gnd 
655 7 |a 1406-16-2  |2 gnd 
655 7 |a 25-hydroxyvitamin D  |2 gnd 
655 7 |a A288AR3C9H  |2 gnd 
689 0 0 |A f  |a Journal Article 
689 0 1 |A f  |a Research Support, Non-U.S. Gov't 
689 0 |5 DE-601 
689 1 0 |a Elderly 
689 1 1 |a Hip fracture 
689 1 2 |a Outcomes 
689 1 3 |a Secondary hyperparathyroidism 
689 1 4 |a Vitamin D 
689 1 |5 DE-601 
689 2 0 |a Parathyroid Hormone 
689 2 1 |a Vitamin D 
689 2 2 |A r  |a 1406-16-2 
689 2 3 |a 25-hydroxyvitamin D 
689 2 4 |A r  |a A288AR3C9H 
689 2 |5 DE-601 
700 1 |a González-Montalvo, J I 
700 1 |a Hoyos, R 
700 1 |a Diez-Sebastián, J 
700 1 |a Otero, A 
700 1 |a Mauleon, J L 
773 0 8 |i in  |t Journal of endocrinological investigation  |g Vol. 38, No. 10 (2015), p. 1129-35  |q 38:10<1129-35  |w (DE-601)NLM000412155  |x 1720-8386 
856 4 1 |u http://dx.doi.org/10.1007/s40618-015-0320-9  |3 Volltext 
912 |a GBV_NLM 
951 |a AR 
952 |d 38  |j 2015  |e 10  |c 10  |h 1129-35