Whole-exome sequencing implicates UBE3D in age-related macular degeneration in East Asian populations

Age-related macular degeneration (AMD) is a leading cause of irreversible central blindness among the elderly worldwide. We use exome sequencing to analyse nonsynonymous single-nucleotide variants (SNVs) across the whole genome of 216 neovascular AMD cases and 1,553 controls. As a follow-up validati...

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Bibliographic Details
Published in:Nature communications, Vol. 6 (2015), p. 6687
Main Author: Huang, Lv-Zhen
Other Involved Persons: Li, Ying-Jie ; Xie, Xue-Feng ; Zhang, Jing-Jing ; Cheng, Ching-Yu ; Yamashiro, Kenji ; Chen, Li-Jia ; Ma, Xiao-Yun ; Cheung, Chui Ming G ; Wang, Yu-Sheng ; Zhang, Chun-Fang ; Bai, Yu-Jing ; Hou, Jing ; Chen, Xiao-Li ; Qi, Yun ; Li, Shan-Shan ; Sun, Yao-Yao ; Mei, Jun-Pu ; Cheng, Yong ; Yu, Wen-Zhen ; Hu, Xiong-Bing ; Zhuang, Feng-Feng ; Fan, Lei ; Lu, Yi ; Sun, Xing-Huai ; Zhu, Xiang-Jia ; Shen, De-Fen ; Chan, Chi-Chao ; Zhao, Ming-Wei ; Yoshimura, Nagahisa ; Pang, Chi Pui ; Wong, Tien Yin ; Khor, Chiea Chuen ; Zhang, Kang ; Zhou, Peng ; Li, Xiao-Xin
Format: electronic Article
Language:English
ISSN:2041-1723
Item Description:Date Completed 05.04.2016
Date Revised 25.11.2016
published: Electronic
Citation Status MEDLINE
Copyright: From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Physical Description:Online-Ressource
DOI:10.1038/ncomms7687
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