Identification of a rare coding variant in complement 3 associated with age-related macular degeneration

Macular degeneration is a common cause of blindness in the elderly. To identify rare coding variants associated with a large increase in risk of age-related macular degeneration (AMD), we sequenced 2,335 cases and 789 controls in 10 candidate loci (57 genes). To increase power, we augmented our cont...

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Bibliographic Details
Published in:Nature genetics, Vol. 45, No. 11 (2013), p. 1375-9
Main Author: Zhan, Xiaowei
Other Involved Persons: Larson, David E ; Wang, Chaolong ; Koboldt, Daniel C ; Sergeev, Yuri V ; Fulton, Robert S ; Fulton, Lucinda L ; Fronick, Catrina C ; Branham, Kari E ; Bragg-Gresham, Jennifer ; Jun, Goo ; Hu, Youna ; Kang, Hyun Min ; Liu, Dajiang ; Othman, Mohammad ; Brooks, Matthew ; Ratnapriya, Rinki ; Boleda, Alexis ; Grassmann, Felix ; von Strachwitz, Claudia ; Olson, Lana M ; Buitendijk, Gabriëlle H S ; Hofman, Albert ; van Duijn, Cornelia M ; Cipriani, Valentina ; Moore, Anthony T ; Shahid, Humma ; Jiang, Yingda ; Conley, Yvette P ; Morgan, Denise J ; Kim, Ivana K ; Johnson, Matthew P ; Cantsilieris, Stuart ; Richardson, Andrea J ; Guymer, Robyn H ; Luo, Hongrong ; Ouyang, Hong ; Licht, Christoph ; Pluthero, Fred G ; Zhang, Mindy M ; Zhang, Kang ; Baird, Paul N ; Blangero, John ; Klein, Michael L ; Farrer, Lindsay A ; DeAngelis, Margaret M ; Weeks, Daniel E ; Gorin, Michael B ; Yates, John R W ; Klaver, Caroline C W ; Pericak-Vance, Margaret A ; Haines, Jonathan L ; Weber, Bernhard H F ; Wilson, Richard K ; Heckenlively, John R ; Chew, Emily Y ; Stambolian, Dwight ; Mardis, Elaine R ; Swaroop, Anand ; Abecasis, Goncalo R
Format: electronic Article
Language:English
ISSN:1061-4036
Item Description:Date Completed 08.01.2014
Date Revised 13.11.2018
published: Print-Electronic
Citation Status MEDLINE
Copyright: From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Physical Description:Online-Ressource
DOI:10.1038/ng.2758
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