Carbohydrate plasma expanders for passive tumor targeting : in vitro and in vivo studies

Copyright © 2013 Elsevier Ltd. All rights reserved.

Bibliographic Details
Published in:Carbohydrate polymers, Vol. 95, No. 1 (2013), p. 404-13
Main Author: Hoffmann, Stefan
Other Involved Persons: Caysa, Henrike ; Kuntsche, Judith ; Kreideweiss, Patrick ; Leimert, Anja ; Mueller, Thomas ; Mäder, Karsten
Format: electronic Article
Language:English
ISSN:1879-1344
Item Description:Date Completed 22.10.2013
Date Revised 25.11.2016
published: Print-Electronic
Citation Status MEDLINE
Copyright: From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Physical Description:Online-Ressource
DOI:10.1016/j.carbpol.2013.03.033
Subjects:
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520 |a The objective of this study was to investigate the suitability of carbohydrate plasma volume expanders as a novel polymer platform for tumor targeting. Many synthetic polymers have already been synthesized for targeted tumor therapy, but potential advantages of these carbohydrates include inexpensive synthesis, constant availability, a good safety profile, biodegradability and the long clinical use as plasma expanders. Three polymers have been tested for cytotoxicity and cytokine activation in cell cultures and conjugated with a near-infrared fluorescent dye: hydroxyethyl starches (HES 200 kDa and HES 450 kDa) and dextran (DEX 500 kDa). Particle size and molecular weight distribution were determined by asymmetric flow field-flow fractionation (AF4). The biodistribution was investigated non-invasively in nude mice using multispectral optical imaging. The most promising polymer conjugate was characterized in human colon carcinoma xenograft bearing nude mice. A tumor specific accumulation of HES 450 was observed, which proves it's potential as carrier for passive tumor targeting 
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