Cholesterol metabolism is associated with soluble amyloid precursor protein production in Alzheimer's disease

© 2012 The Authors Journal of Neurochemistry © 2012 International Society for Neurochemistry.

Bibliographic Details
Published in:Journal of neurochemistry, Vol. 123, No. 2 (2012), p. 310-6
Main Author: Popp, Julius
Other Involved Persons: Lewczuk, Piotr ; Kölsch, Heike ; Meichsner, Sabrina ; Maier, Wolfgang ; Kornhuber, Johannes ; Jessen, Frank ; Lütjohann, Dieter
Format: electronic Article
Language:English
ISSN:1471-4159
Item Description:Date Completed 11.12.2012
Date Revised 25.11.2016
published: Print-Electronic
Citation Status MEDLINE
Copyright: From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Physical Description:Online-Ressource
DOI:10.1111/j.1471-4159.2012.07893.x
Subjects:
QR Code: Show QR Code
LEADER 04261nma a2200829 c 4500
001 NLM219761795
003 DE-601
005 20181228111655.0
007 cr uuu---uuuuu
008 180205s2012 000 0 eng d
024 7 |a 10.1111/j.1471-4159.2012.07893.x  |2 doi 
028 5 2 |a pubmed19n0732.xml 
035 |a (DE-599)NLM22845771 
040 |b ger  |c GBVCP 
041 0 |a eng 
100 1 |a Popp, Julius 
245 1 0 |a Cholesterol metabolism is associated with soluble amyloid precursor protein production in Alzheimer's disease  |h Elektronische Ressource 
300 |a Online-Ressource 
500 |a Date Completed 11.12.2012 
500 |a Date Revised 25.11.2016 
500 |a published: Print-Electronic 
500 |a Citation Status MEDLINE 
500 |a Copyright: From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine 
520 |a © 2012 The Authors Journal of Neurochemistry © 2012 International Society for Neurochemistry. 
520 |a Disturbances of the cholesterol metabolism are associated with Alzheimer's disease (AD) risk and related cerebral pathology. Experimental studies found changing levels of cholesterol and its metabolites 24S-hydroxycholesterol (24S-OHC) and 27-hydroxycholesterol (27-OHC) to contribute to amyloidogenesis by increasing the production of soluble amyloid precursor protein (sAPP). The aim of this study was to evaluate the relationship between the CSF and circulating cholesterol 24S-OHC and 27-OHC, and the sAPP production as measured by CSF concentrations of sAPP forms in humans. The plasma and the CSF concentrations of cholesterol, 24S-OHC and 27-OHC, and the CSF concentrations of sAPPα, sAPPβ, and Aß1-42 were assessed in subjects with AD and controls with normal cognition. In multivariate regression tests including age, gender, albumin ratio, and apolipoprotein E (APOE)ε4 status CSF cholesterol, 24S-OHC, and 27-OHC independently predicted the concentrations of sAPPα and sAPPβ. The associations remained significant when analyses were separately performed in the AD group. Furthermore, plasma 27-OHC concentrations were associated with the CSF sAPP levels. The results suggest that high CSF concentrations of cholesterol, 24S-OHC, and 27-OHC are associated with increased production of both sAPP forms in AD 
611 2 7 |a Journal Article  |2 gnd 
611 2 7 |a Research Support, Non-U.S. Gov't  |2 gnd 
653 2 |a Aged  |6 D000368 
653 2 |a Alzheimer Disease  |6 D000544  |a diagnosis  |6 Q000175  |a *metabolism  |6 Q000378 
653 2 |a Amyloid beta-Protein Precursor  |6 D016564  |a *biosynthesis  |6 Q000096 
653 2 |a Biomarkers  |6 D015415  |a blood  |6 Q000097  |a cerebrospinal fluid  |6 Q000134 
653 2 |a Cholesterol  |6 D002784  |a *metabolism  |6 Q000378 
653 2 |a Female  |6 D005260 
653 2 |a Humans  |6 D006801 
653 2 |a Hydroxycholesterols  |6 D006888  |a metabolism  |6 Q000378 
653 2 |a Male  |6 D008297 
653 2 |a Middle Aged  |6 D008875 
653 2 |a Up-Regulation  |6 D015854  |a physiology  |6 Q000502 
655 7 |a Amyloid beta-Protein Precursor  |2 gnd 
655 7 |a Biomarkers  |2 gnd 
655 7 |a Hydroxycholesterols  |2 gnd 
655 7 |a 24-hydroxycholesterol  |2 gnd 
655 7 |a 47IMW63S3F  |2 gnd 
655 7 |a 27-hydroxycholesterol  |2 gnd 
655 7 |a 6T2NA6P5SQ  |2 gnd 
655 7 |a Cholesterol  |2 gnd 
655 7 |a 97C5T2UQ7J  |2 gnd 
689 0 0 |A f  |a Journal Article 
689 0 1 |A f  |a Research Support, Non-U.S. Gov't 
689 0 |5 DE-601 
689 2 0 |a Amyloid beta-Protein Precursor 
689 2 1 |a Biomarkers 
689 2 2 |a Hydroxycholesterols 
689 2 3 |a 24-hydroxycholesterol 
689 2 4 |A r  |a 47IMW63S3F 
689 2 5 |a 27-hydroxycholesterol 
689 2 6 |A r  |a 6T2NA6P5SQ 
689 2 7 |a Cholesterol 
689 2 8 |A r  |a 97C5T2UQ7J 
689 2 |5 DE-601 
700 1 |a Lewczuk, Piotr 
700 1 |a Kölsch, Heike 
700 1 |a Meichsner, Sabrina 
700 1 |a Maier, Wolfgang 
700 1 |a Kornhuber, Johannes 
700 1 |a Jessen, Frank 
700 1 |a Lütjohann, Dieter 
773 0 8 |i in  |t Journal of neurochemistry  |g Vol. 123, No. 2 (2012), p. 310-6  |q 123:2<310-6  |w (DE-601)NLM000006211  |x 1471-4159 
856 4 1 |u http://dx.doi.org/10.1111/j.1471-4159.2012.07893.x  |3 Volltext 
912 |a GBV_NLM 
951 |a AR 
952 |d 123  |j 2012  |e 2  |c 10  |h 310-6