A non-invasive, low-cost study design to determine the release profile of colon drug delivery systems : a feasibility study

PURPOSE: Conventional bioavailability testing of dosage forms based on plasma concentration-time graphs of two products in a two-period, crossover-design, is not applicable to topical treatment of intestinal segments. We introduce an isotope dual-label approach ((13)C- and (15)N(2)-urea) for colon d...

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Bibliographic Details
Published in:Pharmaceutical research, Vol. 29, No. 8 (2012), p. 2070-8
Main Author: Maurer, Marina J M
Other Involved Persons: Schellekens, Reinout C A ; Wutzke, Klaus D ; Dijkstra, Gerard ; Woerdenbag, Herman J ; Frijlink, Henderik W ; Kosterink, Jos G W ; Stellaard, Frans
Format: electronic Article
Language:English
ISSN:1573-904X
Item Description:Date Completed 23.11.2012
Date Revised 13.11.2018
published: Print-Electronic
Citation Status MEDLINE
Copyright: From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Physical Description:Online-Ressource
DOI:10.1007/s11095-012-0735-3
Subjects:
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