Dual fluorescent HPMA copolymers for passive tumor targeting with pH-sensitive drug release : synthesis and characterization of distribution and tumor accumulation in mice by noninvasive multispectral optical imaging

Preclinical in vivo characterization of new polymeric drug conjugate candidates is crucial for understanding the effects of certain chemical modifications on distribution and elimination of these carrier systems, which is the basis for rational drug design. In our study we synthesized dual fluoresce...

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Bibliographic Details
Published in:Biomacromolecules, Vol. 13, No. 3 (2012), p. 652-63
Main Author: Hoffmann, Stefan
Other Involved Persons: Vystrčilová, Lucie ; Ulbrich, Karel ; Etrych, Tomáš ; Caysa, Henrike ; Mueller, Thomas ; Mäder, Karsten
Format: electronic Article
Language:English
ISSN:1526-4602
Item Description:Date Completed 17.07.2012
Date Revised 25.11.2016
published: Print-Electronic
Citation Status MEDLINE
Copyright: From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Physical Description:Online-Ressource
DOI:10.1021/bm2015027
Subjects:
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