Clarithromycin is absorbed by an intestinal uptake mechanism that is sensitive to major inhibition by rifampicin : results of a short-term drug interaction study in foals

Pulmonary penetration of clarithromycin (CLR) in epithelial lining fluid (ELF) and bronchoalveolar lavage cells (BALCs) can be influenced by CYP3A4, by P-glycoprotein, and, according to our hypothesis, by a member of the organic anion-transporting protein (OATP) family, for which rifampicin (RIF) is...

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Bibliographic Details
Published in:Drug metabolism and disposition: the biological fate of chemicals, Vol. 40, No. 3 (2012), p. 522-8
Main Author: Peters, Jette (Author)
Other Involved Persons: Eggers, Karen ; Oswald, Stefan ; Block, Wiebke ; Lütjohann, Dieter ; Lämmer, Marc ; Venner, Monica ; Siegmund, Werner
Format: electronic Article
Language:English
ISSN:1521-009X
Item Description:Date Completed 07.08.2012
Date Revised 01.12.2018
published: Print-Electronic
Citation Status MEDLINE
Copyright: From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Physical Description:Online-Ressource
DOI:10.1124/dmd.111.042267
Subjects:
Journal Article
Research Support, Non-U.S. Gov't
Animals
Clarithromycin > analogs & derivatives > metabolism > *pharmacokinetics
Drug Interactions
Female
HEK293 Cells
Horses
Humans
Intestinal Absorption > *drug effects
Intestinal Mucosa > *metabolism
Intestines > *drug effects
Lung > drug effects > metabolism
Male
Organic Anion Transporters > metabolism
Respiratory Mucosa > drug effects > metabolism
Rifampin > pharmacokinetics > *pharmacology
Transfection > methods
Up-Regulation > drug effects
Organic Anion Transporters
14-hydroxyclarithromycin
110671-78-8
Clarithromycin
H1250JIK0A
Rifampin
VJT6J7R4TR
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Published in:
Drug metabolism and disposition: the biological fate of chemicals, Vol. 40, No. 3 (2012), p. 522-8
Further Information:
http://dx.doi.org/10.1124/dmd.111.042267
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