Statins promote the degradation of extracellular amyloid {beta}-peptide by microglia via stimulation of exosome-associated insulin-degrading enzyme (IDE) secretion

Epidemiological studies indicate that intake of statins decrease the risk of developing Alzheimer disease. Cellular and in vivo studies suggested that statins might decrease the generation of the amyloid β-peptide (Aβ) from the β-amyloid precursor protein. Here, we show that statins potently stimula...

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Bibliographic Details
Published in:The Journal of biological chemistry, Vol. 285, No. 48 (2010), p. 37405-14
Main Author: Tamboli, Irfan Y (Author)
Other Involved Persons: Barth, Esther ; Christian, Leonie ; Siepmann, Martin ; Kumar, Sathish ; Singh, Sandesh ; Tolksdorf, Karen ; Heneka, Michael T ; Lütjohann, Dieter ; Wunderlich, Patrick ; Walter, Jochen
Format: electronic Article
Language:English
ISSN:1083-351X
Item Description:Date Completed 30.12.2010
Date Revised 13.11.2018
published: Print-Electronic
Citation Status MEDLINE
Copyright: From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Physical Description:Online-Ressource
DOI:10.1074/jbc.M110.149468
Subjects:
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