Sex steroids inhibit osmotic swelling of retinal glial cells

Osmotic swelling of glial cells may contribute to the development of retinal edema. We investigated whether sex steroids inhibit the swelling of glial somata in acutely isolated retinal slices and glial cells of the rat. Superfusion of retinal slices or cells from control animals with a hypoosmolar...

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Bibliographic Details
Published in:Neurochemical research, Vol. 35, No. 4 (2010), p. 522-30
Main Author: Neumann, Florian
Other Involved Persons: Wurm, Antje ; Linnertz, Regina ; Pannicke, Thomas ; Iandiev, Ianors ; Wiedemann, Peter ; Reichenbach, Andreas ; Bringmann, Andreas
Format: electronic Article
Language:English
ISSN:1573-6903
Item Description:Date Completed 02.08.2010
Date Revised 13.11.2018
published: Print
Citation Status MEDLINE
Copyright: From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Physical Description:Online-Ressource
DOI:10.1007/s11064-009-0092-8
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  • Osmotic swelling of glial cells may contribute to the development of retinal edema. We investigated whether sex steroids inhibit the swelling of glial somata in acutely isolated retinal slices and glial cells of the rat. Superfusion of retinal slices or cells from control animals with a hypoosmolar solution did not induce glial swelling, whereas glial swelling was observed in slices of postischemic and diabetic retinas. Progesterone, testosterone, estriol, and 17beta-estradiol prevented glial swelling with half-maximal effects at approximately 0.3, 0.6, 6, and 20 microM, respectively. The effect of progesterone was apparently mediated by transactivation of metabotropic glutamate receptors, P2Y1, and adenosine A1 receptors. The data suggest that sex steroids may inhibit cytotoxic edema in the retina