Dynamic regulation of alternative splicing by silencers that modulate 5' splice site competition

Alternative splicing makes a major contribution to proteomic diversity in higher eukaryotes with approximately 70% of genes encoding two or more isoforms. In most cases, the molecular mechanisms responsible for splice site choice remain poorly understood. Here, we used a randomization-selection appr...

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Bibliographic Details
Published in:Cell, Vol. 135, No. 7 (2008), p. 1224-36
Main Author: Yu, Yang
Other Involved Persons: Maroney, Patricia A ; Denker, John A ; Zhang, Xiang H-F ; Dybkov, Olexandr ; Lührmann, Reinhard ; Jankowsky, Eckhard ; Chasin, Lawrence A ; Nilsen, Timothy W
Format: electronic Article
Language:English
ISSN:1097-4172
Item Description:Date Completed 12.01.2009
Date Revised 13.11.2018
published: Print
Citation Status MEDLINE
Copyright: From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Physical Description:Online-Ressource
DOI:10.1016/j.cell.2008.10.046
Subjects:
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