Chronic morphine use does not induce peripheral tolerance in a rat model of inflammatory pain

Although opioids are highly effective analgesics, they are also known to induce cellular adaptations resulting in tolerance. Experimental studies are often performed in the absence of painful tissue injury, which precludes extrapolation to the clinical situation. Here we show that rats with chronic...

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Bibliographic Details
Published in:The Journal of clinical investigation, Vol. 118, No. 3 (2008), p. 1065-73
Main Author: Zöllner, Christian
Other Involved Persons: Mousa, Shaaban A ; Fischer, Oliver ; Rittner, Heike L ; Shaqura, Mohammed ; Brack, Alexander ; Shakibaei, Mehdi ; Binder, Waltraud ; Urban, Florian ; Stein, Christoph ; Schäfer, Michael
Format: electronic Article
Language:English
ISSN:1558-8238
Item Description:Date Completed 22.04.2008
Date Revised 13.11.2018
published: Print
Citation Status MEDLINE
Copyright: From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Physical Description:Online-Ressource
DOI:10.1172/JCI25911
Subjects:
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