Impact of the SLCO1B1 polymorphism on the pharmacokinetics and lipid-lowering efficacy of multiple-dose pravastatin

BACKGROUND AND OBJECTIVE: The polymorphism of SLCO1B1 (solute carrier organic anion transporter family, member 1B1), encoding the hepatic uptake transporter organic anion transporting polypeptide 1B1, has been associated with increased pravastatin concentrations in single-dose studies. We have inves...

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Bibliographic Details
Published in:Clinical pharmacology and therapeutics, Vol. 79, No. 5 (2006), p. 419-26
Main Author: Igel, Michael (Author)
Other Involved Persons: Arnold, Katja A ; Niemi, Mikko ; Hofmann, Ute ; Schwab, Matthias ; Lütjohann, Dieter ; von Bergmann, Klaus ; Eichelbaum, Michel ; Kivistö, Kari T
Format: Article
Item Description:Date Completed 05.06.2006
Date Revised 01.12.2018
published: Print-Electronic
Citation Status MEDLINE
Copyright: From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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