Intestinal expression of P-glycoprotein (ABCB1), multidrug resistance associated protein 2 (ABCC2), and uridine diphosphate-glucuronosyltransferase 1A1 predicts the disposition and modulates the effects of the cholesterol absorption inhibitor ezetimibe in humans

BACKGROUND AND AIMS: Ezetimibe is an inhibitor of the cholesterol uptake transporter Niemann-Pick C1-like protein (NPC1L1). Target concentrations can be influenced by intestinal uridine diphosphate-glucuronosyltransferases (UGTs) and the efflux transporters P-glycoprotein (P-gp) (ABCB1) and multidru...

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Bibliographic Details
Published in:Clinical pharmacology and therapeutics, Vol. 79, No. 3 (2006), p. 206-17
Main Author: Oswald, Stefan
Other Involved Persons: Haenisch, Sierk ; Fricke, Christiane ; Sudhop, Thomas ; Remmler, Cornelia ; Giessmann, Thomas ; Jedlitschky, Gabriele ; Adam, Ulrike ; Dazert, Eike ; Warzok, Rolf ; Wacke, Wolfram ; Cascorbi, Ingolf ; Kroemer, Heyo K ; Weitschies, Werner ; von Bergmann, Klaus ; Siegmund, Werner
Format: Article
Item Description:Date Completed 04.04.2006
Date Revised 01.12.2018
published: Print-Electronic
Citation Status MEDLINE
Copyright: From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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