Disposition of oral and intravenous pravastatin in MRP2-deficient TR- rats

The aim of this study was to characterize the role of the efflux transporter Mrp2 (Abcc2) in the pharmacokinetics of orally and intravenously administered pravastatin in rats. Eight Mrp2-deficient TR- rats and eight wild-type rats were given an oral dose of 20 mg/kg pravastatin. Four TR- animals and...

Full description

Bibliographic Details
Published in:Drug metabolism and disposition: the biological fate of chemicals, Vol. 33, No. 11 (2005), p. 1593-6
Main Author: Kivistö, Kari T
Other Involved Persons: Grisk, Olaf ; Hofmann, Ute ; Meissner, Konrad ; Möritz, Klaus-Uwe ; Ritter, Christoph ; Arnold, Katja A ; Lutjöohann, Dieter ; von Bergmann, Klaus ; Klöting, Ingrid ; Eichelbaum, Michel ; Kroemer, Heyo K
Format: Article
Item Description:Date Completed 04.08.2006
Date Revised 13.12.2017
published: Print-Electronic
Citation Status MEDLINE
Copyright: From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
QR Code: Show QR Code