Adaptive statistical analysis following sample size modification based on interim review of effect size

In designing a comparative clinical trial, the required sample size is a function of the effect size, the value of which is unknown and at best may be estimated from historical data. Insufficiency in sample size as a result of overestimating the effect size can be destructive to the success of the c...

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Bibliographic Details
Published in:Journal of biopharmaceutical statistics, Vol. 15, No. 4 (2005), p. 693-706
Main Author: Hung, H M James (Author)
Other Involved Persons: Cui, Lu ; Wang, Sue-Jane ; Lawrence, John
Format: Article
Item Description:Date Completed 14.09.2005
Date Revised 15.11.2007
published: Print
Citation Status MEDLINE
Copyright: From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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