Cerebrospinal fluid 24S-hydroxycholesterol is increased in patients with Alzheimer's disease compared to healthy controls

Experiments in cell cultures indicate that accumulation of cholesterol in hippocampal neurons results in an accelerated cleavage of amyloid precursor protein into amyloidogenic components. To be eliminated from the brain, cholesterol is converted to 24S-hydroxycholesterol which may reflect cerebral...

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Bibliographic Details
Published in:Neuroscience letters, Vol. 324, No. 1 (2002), p. 83-5
Main Author: Schönknecht, Peter
Other Involved Persons: Lütjohann, Dieter ; Pantel, Johannes ; Bardenheuer, Habertus ; Hartmann, Tobias ; von Bergmann, Klaus ; Beyreuther, Konrad ; Schröder, Johannes
Format: Article
Item Description:Date Completed 12.07.2002
Date Revised 01.07.2019
published: Print
Citation Status MEDLINE
Copyright: From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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