Relationship between CYP2C9 and 2C19 genotypes and tolbutamide methyl hydroxylation and S-mephenytoin 4'-hydroxylation activities in livers of Japanese and Caucasian populations

Genomic DNA was isolated from livers of 39 Japanese and 45 Caucasians and the genotypes of CYP2C9 and 2C19 genes were determined with PCR methods using synthetic oligonucleotide primers. Liver microsomes were also prepared from these human samples and activities for tolbutamide methyl hydroxylation...

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Bibliographic Details
Published in:Pharmacogenetics, Vol. 7, No. 2 (1997), p. 103-13
Main Author: Inoue, K
Other Involved Persons: Yamazaki, H ; Imiya, K ; Akasaka, S ; Guengerich, F P ; Shimada, T
Format: Article
Item Description:Date Completed 29.07.1997
Date Revised 24.10.2019
published: Print
Citation Status MEDLINE
Copyright: From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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