B cells of aging rats : impaired stimulus-secretion coupling but normal susceptibility to adverse effects of a diabetic state

A diabetic state impairs B-cell function and survival. We tested whether the negative effects are exacerbated by the aging process. Islets were isolated from old (63.3 +/- 2.3 weeks) and young (11.3 +/- 0.5 weeks) inbred Wistar rats. Age did not affect DNA and insulin content, yet both glucose-induc...

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Bibliographic Details
Published in:Metabolism: clinical and experimental, Vol. 46, No. 3 (1997), p. 242-6
Main Author: Inoue, K
Other Involved Persons: Norgren, S ; Luthman, H ; Möller, C ; Grill, V
Format: Article
Item Description:Date Completed 31.03.1997
Date Revised 25.07.2019
published: Print
Citation Status MEDLINE
Copyright: From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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