Alternatives to laboratory animals : ATLA

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Title Year of Publication
Conference Diary Elektronische Ressource 2019
ATLA Evolves to the Next Stage Elektronische Ressource FRAME is partnering with SAGE Publishing to take ATLA forward 2019
Reference Gene Validation for Quantitative Real-time PCR Studies in Amphibian Kidney-derived A6 Epithelial Cells Elektronische Ressource 2019
Non-pooled Human Platelet Lysate Elektronische Ressource A Potential Serum Alternative for In Vitro Cell Culture 2019
News & Views Elektronische Ressource 2019
Experimental Animal Use in Turkey Elektronische Ressource A Comparison with Other Countries 2019
Retinal Organ Cultures as Alternative Research Models Elektronische Ressource 2019
News & Views Elektronische Ressource 2019
CAAT News & Views Elektronische Ressource 2019
Short-term and Long-term Exposure of the MucilAir™ Model to Polycyclic Aromatic Hydrocarbons Elektronische Ressource 2019
The 2020 Lush Prize Elektronische Ressource Call for Nominations 2019
Conference Diary Elektronische Ressource 2019
Brazil Moves Toward the Replacement of Animal Experimentation Elektronische Ressource 2019
News & Views Elektronische Ressource 2019
Pushing the Partnership Forward Elektronische Ressource 2019
CAAT News & Views Elektronische Ressource 2019
Conscientious Objection to Animal Testing Elektronische Ressource A Preliminary Survey Among Italian Medical and Veterinary Students 2019
FRAME 50th Anniversary Symposium, July 2019 Elektronische Ressource 2019
Is live-tissue training ethically justified? An evidence-based ethical analysis 2018
Animal research for type 2 diabetes mellitus, its limited translation for clinical benefit, and the way forward 2018
Where to draw the line? Should the age of protection for zebrafish be lowered? 2018
Replacing animal use in education and training 2018
The use of animals in contemporary medical research - if not animals, then who or what? 2018
Exploring the use of alternatives to animals in undergraduate education in Australia 2018
Applicability of the Monocyte Activation Test (MAT) in the quality control of the 17DD yellow fever vaccine 2018
Ten years of REACH - An animal protection perspective 2018
Severity classification of surgical procedures and application of health monitoring strategies in animal research proposals A retrospective review 2018
The myth of Replacement and the legal reality 2018
A comparison of pyrogen detection tests in the quality control of meningococcal conjugate vaccines The applicability of the Monocyte Activation Test 2018
Electronic cigarettes can dependable public health policies be developed and applied without relevant and reliable risk assessments? 2018
A survey to understand public opinion regarding animal use in medical training 2018
Why are validated alternatives not being used to replace animal tests? 2018
2017 Lush Science Prize 2018
Characterisation of a canine epithelial cell line for modelling the intestinal barrier 2018
Phase 0, including microdosing approaches Applying the Three Rs and increasing the efficiency of human drug development 2018
Murine alveolar epithelial cells and their lentivirus-mediated immortalisation 2018
Does the stress of laboratory life and experimentation on animals adversely affect research data? A critical review 2018
The application of humane endpoints and humane killing methods in animal research proposals A retrospective review 2018
In vitro human tissues via multi-material 3-D bioprinting 2018
Questionable progress in the application of the Three Rs to improve science, human well-being and animal welfare 2018
The replacement of animal tests 2018
A review of the contributions of cross-discipline collaborative European IMI/EFPIA research projects to the development of Replacement, Reduction and Refinement strategies 2018
The development of a clinical skills laboratory at Ross University School of Medicine 2018
The 2017 Lush Prize Awards 2018
Brazil starts to ban animal use in higher education A positive and progressive development 2018
Sample size estimation for pilot animal experiments by using a Markov Chain Monte Carlo approach 2017
Does the stress inherent to laboratory life and experimentation on animals adversely affect research data? 2017
The use of neurocomputational models as alternatives to animal models in the development of electrical brain stimulation treatments 2017
White paper and colourful language Toward a realistic view of animal research 2017
Letter to the Editor 2017
The use of animals in medical research - a historical perspective 2017
New animal-free concepts and test methods for developmental toxicity and peripheral neurotoxicity 2017
The perception of animal experimentation ethics among Indian teenage school pupils 2017
On the journey toward humane education in Brazil First request for a total ban of harmful animal use in professional and higher education 2017
In vitro models as a platform to investigate traumatic brain injury 2017
Human aortic endothelial cells respond to shear flow in well-plate microfluidic devices 2017
No time like the present - two hundred years of Parkinson's disease 2017
Use of the Bovine Udder Skin model to evaluate the tolerability of Mesem cosmetic cream 2017
Animal experimentation and alternatives revealed preferences 2017
Fetal Bovine Serum (FBS) - A pain in the dish? 2017
Animal experiments and the right to ask questions about them 2017
Harmonisation of animal testing alternatives in China 2017
High-throughput prediction of nephrotoxicity in humans 2017
Launch of the Alliance for Human Relevant Science 2017
Training and good science are the foundation stones for animal replacement 2017
In vitro exposure systems and dosimetry assessment tools for inhaled tobacco products Workshop proceedings, conclusions and paths forward for in vitro model use 2017
The 2016 Lush Prize Awards 2017
2016 Lush Science Prize 2017
Evaluation of a human neural stem cell culture method for prediction of the neurotoxicity of anti-epileptics 2017
Some personal reminiscences of the long road to acceptance of the Three Rs 2017
Animal 'models' How a mechanistic approach can reduce suffering and improve translatability 2017
Pain in laboratory animals A possible confounding factor? 2017
A novel porcine ex vivo retina culture model for oxidative stress induced by H₂O₂ 2017
A comparison of scaffold-free and scaffold-based reconstructed human skin models as alternatives to animal use 2017
The use of gatekeeping procedures in the statistical planning of animal experiments 2017
2015 Lush Science Prize 2016
Autologous co-culture of primary human alveolar macrophages and epithelial cells for investigating aerosol medicines. Part I model characterisation 2016
The use of peptide reactivity assays for skin sensitisation hazard identification and risk assessment 2016
The adverse outcome pathway concept A basis for developing regulatory decision-making tools 2016
The 2015 Lush Prize Awards 2016
The use of a decision tree based on the rabies diagnosis scenario, to assist the implementation of alternatives to laboratory animals 2016
The novel induction of retinal ganglion cell apoptosis in porcine organ culture by NMDA - an opportunity for the replacement of animals in experiments 2016
Statistics of Scientific Procedures on Living Animals Great Britain 2015 - highlighting an ongoing upward trend in animal use and missed opportunities 2016
Brazilian Center for the Validation of Alternative Methods (BraCVAM) and the process of validation in Brazil 2016
The adverse outcome pathway for skin sensitisation Moving closer to replacing animal testing 2016
Establishment of a tumour-stroma airway model (OncoCilAir) to accelerate the development of human therapies against lung cancer 2016
A training course on laboratory animal science an initiative to implement the Three Rs of animal research in India 2016
Acute oral toxicity testing Scientific evidence and practicability should govern Three Rs activities 2016
Skin sensitisation, adverse outcome pathways and alternatives 2016
Nrf2 activation as a key event triggered by skin sensitisers The development of the stable KeratinoSens reporter gene assay 2016
A comparative evaluation of six principal IgY antibody extraction methods 2016
More than 70 years of pyrogen detection Current state and future perspectives 2016
Expectations for the methodology and translation of animal research a survey of the general public, medical students and animal researchers in North America 2016
Autologous co-culture of primary human alveolar macrophages and epithelial cells for investigating aerosol medicines. Part II evaluation of IL-10-loaded microparticles for the treatment of lung inflammation 2016
First thoughts on the effects on the protection of laboratory animals of the UK's departure from the European Union 2016
Exploring waiving opportunities for mammalian acute systemic toxicity tests 2016
Evaluation of an in vitro cell culture assay for the potency assessment of recombinant human erythropoietin 2016
Statistics of Scientific Procedures on Living Animals 2014 A new format, and hopefully a new era of diminishing animal experimentation? 2016
Why does our concern for animals cease when we leave the laboratory? 2016
Non-human primates in neuroscience research The case against its scientific necessity 2016
The European Citizens' Stop Vivisection Initiative and the revision of Directive 2016
Animal experimentation the statistics speak for themselves 2016
Local tolerance testing under REACH Accepted non-animal methods are not on equal footing with animal tests 2016
Evaluation of non-animal methods for assessing skin sensitisation hazard A Bayesian Value-of-Information analysis 2016
It takes a village Stakeholder participation is essential to transforming science 2016
Body-on-a-chip systems for animal-free toxicity testing 2016
Animal experimentation Oh, when will they ever learn? 2016
A multi-faceted approach to achieving the global acceptance of animal-free research methods 2016
Transparency and public involvement in animal research 2016
Concerns that animal testing continues without scientific justification 2016
Assessment of in vitro COPD models for tobacco regulatory science Workshop proceedings, conclusions and paths forward for in vitro model use 2016
Stakeholder views on the creation and use of genetically-engineered animals in research 2016
The use of in vivo, ex vivo, in vitro, computational models and volunteer studies in vision research and therapy, and their contribution to the Three Rs 2016
Comparing the CORAL and Random Forest approaches for modelling the in vitro cytotoxicity of silica nanomaterials 2016
Scientific issues raised by the use of dogs as laboratory animals 2016
Attitudes toward the use of animals in chronic versus acute pain research results of a web-based forum 2016
In vitro assessment of skin irritation potential of surfactant-based formulations by using a 3-D skin reconstructed tissue model and cytokine response 2016
Non-animal Replacements for Acute Toxicity Testing 2015
Young researchers--the ethical challenge 2015
20. On replacing the concept of Replacement 2015
15. Comparative substitution 2015
Do e-cigarettes pose a risk to human health? 2015
Monkey-based Research on Human Disease The Implications of Genetic Differences 2015
Coffee in class Elektronische Ressource an alternative to animal experiments in pharmacology? 2015
The protozoan, Paramecium primaurelia, as a non-sentient model to test laser light irradiation The effects of an 808nm infrared laser diode on cellular respiration 2015
Development and validation of a low-fidelity simulator to suture a laparotomy in rabbits 2015
Humane Education in Brazil Organisation, Challenges and Opportunities 2015
Toward the Replacement of Animal Experiments through the Bioinformatics-driven Analysis of 'Omics' Data from Human Cell Cultures 2015
The EpiOcular Eye Irritation Test (EIT) for hazard identification and labelling of eye irritating chemicals protocol optimisation for solid materials and the results after extended shipment 2015
Barriers to the Uptake of Human-based Test Methods, and How to Overcome Them 2015
Conditions and possible mechanisms of VCD-induced ovarian failure 2015
Human embryonal carcinoma cells in serum-free conditions as an in vitro model system of neural differentiation 2015
A critical assessment of the scientific basis, and implementation, of regulations for the safety assessment and marketing of innovative tobacco-related products 2015
In vitro methodologies in ecotoxicological hazard assessment Elektronische Ressource the case of bioaccumulation testing for fish 2015
The EpiOcular™ Eye Irritation Test is the Method of Choice for the In Vitro Eye Irritation Testing of Agrochemical Formulations Correlation Analysis of EpiOcular Eye Irritation Test and BCOP Test Data According to the UN GHS, US EPA and Brazil ANVISA Classification Schemes 2015
Scandinavia and the replacement of in vivo toxicity tests Some personal reflections. The 2015 Bjorn Ekwall Memorial Award Lecture 2015
The use of animals in experiments - not because of lack of empathy? 2015
Comparative costs of the Mouse Inoculation Test (MIT) and Virus Isolation in Cell Culture (VICC) for use in rabies diagnosis in Brazil 2015
The Ex Vivo Eye Irritation Test as an alternative test method for serious eye damage/eye irritation 2015
SEARCHBreast Workshop Proceedings 3D Modelling of Breast Cancer 2015
Toxicity assessment of tobacco products in vitro 2015
Likelihood ratios in assessing the safety of new medicines 2015
The use of 3-D models as alternatives to animal testing 2015
The cost of standing strong for replacement 2015
3-D tissue modelling and virtual pathology as new approaches to study ductal carcinoma in situ 2015
On the safety of e-cigarettes Elektronische Ressource "I can resist anything except temptation" 2015
Participation of Brazil in the World Congresses on Alternatives and Animal Use in the Life Sciences an increase in commitment to the Three Rs 2015
17. The Choice of Procedures 2015
The 2014 Lush Prize awards 2015
How long must they suffer? success and failure of our efforts to end the animal tragedy in laboratories 2015
16. The Three Rs Elektronische Ressource the way forward 2015
Dear Editor Elektronische Ressource 2015
The European Citizens' Stop Vivisection Initiative 2015
Turning apples into oranges? The harm-benefit analysis and how to take ethical considerations into account Elektronische Ressource 2015
Optimisation of the bovine whole in vitro embryo system as a sentinel for toxicity screening a cadmium challenge 2015
Single Housing of Primates in US Laboratories A Growing Problem with Shrinking Transparency 2015
Peer review and the Three Rs A challenge to integrity? 2015
18. Rationalisation and intellectualisation 2015
More noise does not mean more precision A review of Aldenberg and Rorije (2013) 2015
A New Approach to Optimising the Use of Animal Models in Drug Discovery through Big Data Sharing 2015
Better science with human cell-based organ and tissue models 2015
Reply on Monkey-based Research on Human Disease The Implications of Genetic Differences 2015
Predicting human drug toxicity and safety via animal tests can any one species predict drug toxicity in any other, and do monkeys help? 2015
In Vitro Models to Mimic the Endothelial Barrier 2015
2014 Lush Science Prize 2015
The 'Genomic Revolution' and its Impact on Medical Research 2015
19. Russell and Burch after 1959 2015
A message to the proponents of animal experimentation the truth shall make you free 2015
Summary and analysis of the currently existing literature data on metal-based nanoparticles published for selected aquatic organisms Applicability for toxicity prediction by (Q)SARs 2015
Read-across for hazard assessment the ugly duckling is growing up 2015
A step forward in the quality control testing of inactivated rabies vaccines - extensive evaluation of European vaccines by using alternative methods to the in vivo potency tests 2015
To be credible, success in "reducing the use of animals in scientific research" must involve the use of fewer animals 2015
Dear Editor 2015
Introduction the Bjorn Ekwall Memorial Award 2015 2015
14. On the proper application of appropriate statistical methods 2014
Openness on animal research the gauntlet has been thrown down 2014
Quantitative structure-sorption relationships of pesticides used in the sugarcane industry in the northern coastal area of Paraíba State, Brazil 2014
ESNATS conference - the use of human embryonic stem cells for novel toxicity testing approaches 2014
Human-based systems in drug and chemical safety testing--toward replacement, the 'single R' 2014
'One R' is the new 'Three Rs' 2014
The virtual pharmacology lab - a repository of free educational resources to support animal-free pharmacology teaching 2014
2013 Lush Public Awareness Prize winner SAFE (Save Animals From Exploitation), New Zealand 2014
Our guiding principles 2014
Statistics of Scientific Procedures on Living Animals 2013 Experimentation continues to rise--the reliance on genetically-altered animals must be addressed 2014
Laboratory animal sciences training in gulf co-operation council countries think globally, act locally 2014
The use of lower organisms 2014
Re Elliot (2014). Personal reflections on veterinary science training and the Three Rs. ATLA 42, P38-P40 2014
Assessing the effects of environmental enrichment on behavioural deficits in C57BL mice 2014
A campaign to end animal testing introducing the PETA International Science Consortium Ltd 2014
Animal use in education in India confusion continues 2014
Statistical methods and software for validation studies on new in vitro toxicity assays 2014
The use of second species in Toxicology testing 2014
Development of an in silico profiler for respiratory sensitisation 2014
Perceived barriers to the adoption of alternatives to laboratory animal use for rabies diagnosis 2014
FRAME's online alternatives timeline goes live 2014
2013 Lush Science Prize 2014
Student perspectives on the use of alternative methods for teaching in veterinary faculties 2014
Mechanistically-based QSARs to describe metabolic constants in mammals 2014
Animal experimentation and alternatives time to say goodbye to the Three Rs and hello to humanity? 2014
A tutorial for analysing the cost-effectiveness of alternative methods for assessing chemical toxicity the case of acute oral toxicity prediction 2014
Missing, presumed killed in action (or the report that never was) 2014
A survey of knowledge of the three Rs concept among lecturers and postgraduate students in Brazil 2014
Locating the middle ground 2014
The application of QSAR approaches to nanoparticles 2014
Personal reflections on veterinary science training and the Three Rs 2014
Ethoxyresorufin-O-deethylase (EROD) activity modulation of 2,3,7,8-tetrachlorodibenzo-p-dioxin and 3,3',4,4',5-pentachlorobiphenyl (PCB 126) in the presence of aqueous suspensions of nano-C60 2014
Every silver lining has a cloud the scientific and animal welfare issues surrounding a new approach to the production of transgenic animals 2014
New techniques for producing transgenic animals - a mixed blessing from both the scientific and animal welfare perspectives 2014
A normal and biotransforming model of the human bronchial epithelium for the toxicity testing of aerosols and solubilised substances 2014
Estimation of the toxicity of silver nanoparticles by using planarian flatworms 2014
9. The toxicity testing problem 2014
The importance of multidisciplinary skills in research and development 2014
Prediction of acute aquatic toxicity toward Daphnia magna by using the GA-kNN method 2014
The Three Rs--opportunities for improving animal welfare and the quality of scientific research 2014
A Three Rs perspective on the mouse bioassay in routine seafood safety testing for algal biotoxins--1 replacement 2014
Ethical animal use in education and training from clinical rotations to ethically sourced cadavers 2014
11. The analysis of direct inhumanity 2014
The QSPR-THESAURUS the online platform of the CADASTER project 2014
Chlorotriazines do not activate the aryl hydrocarbon receptor, the oestrogen receptor or the thyroid receptor in in vitro assays 2014
Lost in translation the need for better tools 2014
2013 Lush Lobbying Prize winner International Council for Animal Protection in OECD Programme (ICAPO) 2014
A severe case of fraudulent blending of fetal bovine serum strengthens the case for serum-free cell and tissue culture applications 2014
Experimental and theoretical studies in the EU FP7 Marie Curie Initial Training Network Project, Environmental ChemOinformatics (ECO) 2014
Animal experimentation transparency and openness mean little, unless accompanied by honesty and accountability 2014
An analysis of the use of animal models in predicting human toxicology and drug safety 2014
Human bioengineered artery models for in vitro atherosclerosis research fact or fiction? 2014
2013 Lush Public Awareness Prize winner PETA, Laboratory Investigations Department, USA 2014
2013 Lush Training Prize winner XCellR8 2014
Monkey-based research on human disease the implications of genetic differences 2014
Wider recommendations for institutions made in the Brown Report following the BUAV investigation into the use of animals at Imperial College London 2014
The 2013 Lush Prize awards 2014
2013 Lush Training Prize winner Anna Maria Bassi's research team, Laboratory of Analysis and Research of Physiopathology (LARF), Department of Experimental Medicine, University of Genova, Italy 2014
2013 Lush Lobbying Prize winner the Swedish Fund for Research without Animal Experiments 2014
Lung fibrosis drug screening and disease biomarker identification with a lung slice culture model and subtracted cDNA Library 2014
Development of a training model for small animal thoracocentesis and chest tube thoracostomy 2014
A 'road map' toward ending severe suffering of animals used in research and testing 2014
A response to the ABPI's letter to the use of dogs in predicting drug Toxicity in humans 2014
Fish as research tools alternatives to in vivo experiments 2013
From descriptors to predicted properties experimental design by using applicability domain estimation 2013
Animal ethics training for postgraduates in medical schools in India catch them young! 2013
Experimental assessment of the environmental fate and effects of triazoles and benzotriazole 2013
Current status of animal welfare and animal rights in China 2013
A critical review of anaesthetised animal models and alternatives for military research, testing and training, with a focus on blast damage, haemorrhage and resuscitation 2013
Balancing reduction and refinement 2013
The 2012 Lush Prize awards 2013
Definition of the applicability domain of the Short Time Exposure (STE) test for predicting the eye irritation of chemicals 2013
Cryopreserved human whole blood a human-based in vitro immunotoxicological system 2013
Transparency and public accountability on the use of non-human primates as laboratory animals needs actions, as well as words 2013
Animal-free toxicology the use of human tissue to replace the use of animals - examples from human biomonitoring and human placental transport studies 2013
Alternatives to animal bioassays for prions 2013
Cigarette smoke-induced morphological transformation of Bhas 42 cells in vitro 2013
Learning to be humane 2013
Laboratory animal ethics course planning in Iran 2013
Progress in promoting the Three Rs in Korea efficiency and consistency 2013
Implementing the in vitro pyrogen test one more step toward replacing animal experimentation 2013
6. Replacement 2013
The current status of laboratory animal ethics in South Africa 2013
Arguments for considering uncertainty in QSAR predictions in hazard and risk assessments 2013
Adverse outcome pathway-based screening strategies for an animal-free safety assessment of chemicals 2013
The need to improve experimental design 2013
An opportunity to refocus on the 'humane' in experimental endpoints moving beyond Directive 2010/63/EU 2013
Prioritisation of polybrominated diphenyl ethers (PBDEs) by using the QSPR-THESAURUS web tool 2013
Laboratory animal welfare and the Three Rs in Korea 2013
The ethics of using laboratory animals to develop medicines for lifestyle diseases 2013
FRAME's alternatives timeline project 2013
Evaluation of the cytotoxic effects of humid lightweight coal ash derived from the disposal of waste on normal human keratinocyte and endothelial cell lines in 2-D and 3-D culture 2013
Computational toxicology is now inseparable from experimental toxicology 2013
Reduction 2013
An analysis of the use of dogs in predicting human toxicology and drug safety 2013
Species Sensitivity Distribution estimation from uncertain (QSAR-based) effects data 2013
When using animal tests or alternative methods, we are also testing ourselves 2013
The increasing use of genetically-altered animals threatens the credibility of Directive 2010/63/EU 2013
A proposed study on the transplacental transport of parabens in the human placental perfusion model 2013
The Three Rs - do we need a new principle? 2013
Is the ethical appraisal of protocols enough to ensure best practice in animal research? 2013
Animal experimentation in the UK probing beyond the rhetoric 2013
Response to the comment published in ATLA, on the declaration on openness on animal research 2013
5. Refinement 2013
Evaluation of CADASTER QSAR models for the aquatic toxicity of (benzo)triazoles and prioritisation by consensus prediction 2013
Development of a vessel organ culture system characterisation of the method and implications for the reduction of animal experiments 2013
Official batch control of rabies veterinary vaccines current situation and perspectives in the European Union 2013
8. UFAW and Major Charles Hume 2013
A vision becoming reality 2013
Brain-derived neurotrophic factor as an indicator of chemical neurotoxicity an animal-free CNS cell culture model 2013
A phantom pig abdomen as an alternative for testing robotic surgical systems our experience 2013
7. The factors governing progress 2013
Uncertainty in QSAR predictions 2013
Read-across estimates of aquatic toxicity for selected fragrances 2013
Comparative studies of apoptosis in Xenopus laevis and mouse thymoma cell lines 2013
Why animal studies are still being used in drug development 2013
Medical waste tissues - breathing life back into respiratory research 2013
Refinement 2013
Is phenylbutazone a genotoxic carcinogen? A weight-of-evidence assessment 2013
Statistics of Scientific Procedures on Living Animals 2012 another increase in experimentation - genetically-altered animals dominate again 2013
Validation of the hepatocyte-like HPCT-1E3 cell line as an in vitro model for the prediction of acute in vivo toxicity 2013
Humane Society International's global campaign to end animal testing 2013
A toolbox for animal welfare education 2013
Ethical review of projects involving non-human primates funded under the European Union's 7th Research Framework Programme 2013
Resistance to cancer in amphibians a role for apoptosis? 2013
The Three Rs in India 2013
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