Synthesis of bleomycin A5 oligonucleotide derivatives and site-specific cleavage of the DNA target

A method for coupling bleomycin A5 to oligonucleotides is proposed. The reaction was carried out between an amino group of a spermidine residue of the Cu(II) complex of bleomycin A5 (Cu(II)Blm-RH) and a 5'-phosphate group of the oligonucleotides d(pCCAAACA) (I), d(pCGTCCTC) (II), d(pT)16 (III),...

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Bibliographic Details
Published in:Bioconjugate chemistry, Vol. 4, No. 3 (1993), p. 189-93
Main Author: Zarytova, V F
Other Involved Persons: Sergeyev, D S ; Godovikova, T S
Format: Article
Item Description:Date Completed 09.08.1993
Date Revised 23.10.2019
published: Print
Citation Status MEDLINE
Copyright: From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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