Evaluation of biochemical criteria for sensitivity of tumor cells to methotrexate by means of mathematic simulation

A mathematical model of the folic acid cycle and of thymidylate, purines, methionine and serine biosynthetic reactions in leukemia L-1210 and Ehrlich ascite tumour cells was developed. This model was used for an analysis of biochemical criteria of different sensitivity of these tumours to methotrexa...

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Bibliographic Details
Published in:Biokhimiia (Moscow, Russia), Vol. 45, No. 4 (1980), p. 609-21
Main Author: Belousova, A K
Other Involved Persons: Gerasimova, G K ; Vorontsov, I N ; Greshilov, M M
Format: Article
Item Description:Date Completed 28.08.1980
Date Revised 21.11.2013
published: Print
Citation Status MEDLINE
Copyright: From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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