Receptor theories and quantitative effect versus dose-concentration relationship

Both in vivo and in vitro, the dissociation constant K not equal to D50. This was shown for morphine in vivo and for several vasoconstrictors in isolated vascular smooth muscle. When Schild plots are made for a pure competitive antagonist the underlying theory requires that the regression line be co...

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Bibliographic Details
Published in:Drug metabolism reviews, Vol. 15, No. 1-2 (1984), p. 345-63
Main Author: Tallarida, R J
Format: Article
Language:English
ISSN:0360-2532
Item Description:Date Completed 13.09.1984
Date Revised 20.11.2014
published: Print
Citation Status MEDLINE
Copyright: From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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