General scheme of the phosphotriester condensation in the oligodeoxyribonucleotide synthesis with arylsulfonyl chlorides and arylsulfonyl azolides

Phosphotriester condensation (RO)(R'O)PO-2 (PDE) + R"OH (RO)(R'O)(R"O)PO (PTE) in the presence of arylsulfonyl chloride (ArSO2Cl) as well as arylsulfonyl azolides proceeds in two steps as revealed by 31P NMR spectroscopy. Pyrophosphotetraester (PPTE) accumulates in over 80% yield...

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Bibliographic Details
Published in:Nucleic acids research, Vol. 12, No. 4 (1984), p. 2091-110
Main Author: Zarytova, V F
Other Involved Persons: Knorre, D G
Format: Article
Language:English
ISSN:1362-4962
Item Description:Date Completed 24.04.1984
Date Revised 01.05.2019
published: Print
Citation Status MEDLINE
Copyright: From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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