Synthesis and properties of modified oligonucleotides

Phosphorothioate oligonucleotide analogs conjugated to cholesteryl by a neutral, 6 atom linker are more effective inhibitors of HIV-1 in cell culture than the corresponding analogs conjugated via a phosphorothioate group. The antiviral activity correlates with the hydrophobic character of the oligon...

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Bibliographic Details
Published in:Nucleic acids symposium series, , No. 24 (1991), p. 75-8
Main Author: Letsinger, R L (Author)
Other Involved Persons: Alul, R A ; Farooqui, F ; Gryaznov, S M ; Kinstler, O
Format: Article
Item Description:Date Completed 25.11.1992
Date Revised 14.11.2007
published: Print
Citation Status MEDLINE
Copyright: From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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