Loss of an Apurinic/Apyrimidinic Site Endonuclease Increases the Mutagenicity of N-methyl-N′-nitro-N-nitrosoguanidine to Escherichia coli

xthA-Escherichia coli, which are missing a major cellular apurinic/apyrimidinic (AP) endonuclease, are 5- to 10-fold more sensitive than xthA+bacteria to mutagenesis by N-methyl-N′-nitro-N-nitrosoguanidine (MNNG) under conditions that induce the ``adaptive response.'' The xthA--dependent m...

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Bibliographic Details
Published in:Proceedings of the National Academy of Sciences of the United States of America, Vol. 84, No. 9 (1987), p. 2891-2895
Main Author: Foster, Patricia L.
Other Involved Persons: Davis, Elaine F.
Format: electronic Article
Physical Description:Online-Ressource
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