Increased expression of multifunctional serine protease, HTRA1, in retinal pigment epithelium induces polypoidal choroidal vasculopathy in mice

Age-related macular degeneration (AMD) is the leading cause of irreversible blindness in the elderly. Wet AMD includes typical choroidal neovascularization (CNV) and polypoidal choroidal vasculopathy (PCV). The etiology and pathogenesis of CNV and PCV are not well understood. Genome-wide association...

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Bibliographic Details
Published in:Proceedings of the National Academy of Sciences of the United States of America, Vol. 108, No. 35 (2011), p. 14578-14583
Main Author: Jones, Alex
Other Involved Persons: Kumar, Sandeep ; Zhang, Ning ; Tong, Zongzhong ; Yang, Jia-Hui ; Watt, Carl ; Anderson, James ; Fillerup, Heather ; McCloskey, Manabu ; Luo, Ling ; Yang, Zhenglin ; Ambati, Balamurali ; Marc, Robert ; Oka, Chio ; Zhang, Kang ; Fu, Yingbin
Format: electronic Article
Language:English
ISSN:1091-6490
Item Description:Copyright: copyright © 1993–2008 National Academy of Sciences of the United States of America
Physical Description:Online-Ressource
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