Proofreading-Defective DNA Polymerase II Increases Adaptive Mutation in Escherichia coli

The role of Escherichia coli DNA polymerase (Pol) II in producing or avoiding mutations was investigated by replacing the chromosomal Pol II gene (polB+) by a gene encoding an exonuclease-deficient mutant Pol II (polBex1). The polBex1 allele increased adaptive mutations on an episome in nondividing...

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Bibliographic Details
Published in:Proceedings of the National Academy of Sciences of the United States of America, Vol. 92, No. 17 (1995), p. 7951-7955
Main Author: Foster, Patricia L.
Other Involved Persons: Gudmundsson, Gudmundur ; Trimarchi, Jeffrey M. ; Cai, Hong ; Goodman, Myron F.
Format: electronic Article
Language:English
ISSN:0027-8424
Item Description:Copyright: Copyright 1995 The National Academy of Sciences of the United States of America
Physical Description:Online-Ressource
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