Hypoxia conditioning enhances neuroprotective effects of aged human bone marrow mesenchymal stem cell-derived conditioned medium against cerebral ischemia in vitro

• Hypoxia conditioning enhances aged BMSC neuroprotection against ischemic stroke. • Secretomes, especially VEGF, play critical role in BMSC-induced therapeutic effects. • Hypoxia conditioning may improve stem cell therapy for stroke.

Bibliographic Details
Published in:Brain research : an international multidisciplinary journal devoted to fundamental research in the brain sciences, Vol. 1725 (2019), p. 0
Main Author: Zhang, Ying
Other Involved Persons: Ma, Longhui ; Su, Yuwen ; Su, Li ; Lan, Xiaoxi ; Wu, Di ; Han, Song ; Li, Junfa ; Kvederis, Lauren ; Corey, Sydney ; Borlongan, Cesar V. ; Ji, Xunming
Format: electronic Article
Language:English
ISSN:1872-6240
Physical Description:Online-Ressource
DOI:10.1016/j.brainres.2019.146432
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