Advances in GBA-associated Parkinson's disease – Pathology, presentation and therapies
GBA mutations are to date the most common genetic risk factor for Parkinson's disease. The GBA gene encodes the lysomal hydrolase glucocerebrosidase. Whilst bi-allelic GBA mutations cause Gaucher disease, both mono- and bi-allelic mutations confer risk for Parkinson's disease. Clinically,...
|Published in:||Neurochemistry international, Vol. 93 (2016), p. 6-25|
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