Inflammation and gene expression in the rat lung after instillation of silica nanoparticles: Effect of size, dispersion medium and particle surface charge

• Silica particles (50nm) caused significantly more inflammation than 200nm in the lung. • Phagocytosis of some types of particles was reduced using BSA as a dispersant. • Particle size was important in determining Nrf2 expression. • Inflammatory effects of silica can be modulated by the dispersion...

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Bibliographic Details
Published in:Toxicology letters : an international journal for the rapid publication of short reports on all aspects of toxicology especially mechanisms of toxicity, Vol. 224, No. 1 (2014), p. 147-156
Main Author: Brown, David M.
Other Involved Persons: Kanase, Nilesh ; Gaiser, Birgit ; Johnston, Helinor ; Stone, Vicki
Format: electronic Article
Physical Description:Online-Ressource
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