Ursodeoxycholic acid impairs atherogenesis and promotes plaque regression by cholesterol crystal dissolution in mice

Atherosclerosis is a chronic inflammatory disease driven primarily by a continuous retention of cholesterol within the subendothelial space where it precipitates to form cholesterol crystals (CC). These CC trigger a complex inflammatory response through activation of the NLRP3 inflammasome and promo...

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Bibliographic Details
Published in:Biochemical and biophysical research communications : BBRC, Vol. 478, No. 1 (2016), p. 356-362
Main Author: Bode, Niklas (Author)
Other Involved Persons: Grebe, Alena ; Kerksiek, Anja ; L├╝tjohann, Dieter ; Werner, Nikos ; Nickenig, Georg ; Latz, Eicke ; Zimmer, Sebastian
Format: electronic Article
Language:English
ISSN:0006-291X
Physical Description:Online-Ressource
DOI:10.1016/j.bbrc.2016.07.047
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