Synthesis and antitumor activity evaluation of quinazoline derivatives bearing piperazine-1-carbodithioate moiety at C4-position
4-Quinazolinylpiperazine-1-carbodithioates 8a–q and 9a–i were synthesized. Most of them exhibited promising cytotoxicity, and 8n induced a dose-dependent G0/G1 phase arrest in HCT-116 cells.
|Published in:||Bioorganic & medicinal chemistry letters : a Tetrahedron publication for rapid dissemination of preliminary communications on all aspects of bioorganic chemistry, medicinal chemistry, bioinorganic chemistry and related disciplines, Vol. 26, No. 19 (2016), p. 4666-4670|
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