Synthesis and antitumor activity evaluation of quinazoline derivatives bearing piperazine-1-carbodithioate moiety at C4-position

4-Quinazolinylpiperazine-1-carbodithioates 8a–q and 9a–i were synthesized. Most of them exhibited promising cytotoxicity, and 8n induced a dose-dependent G0/G1 phase arrest in HCT-116 cells.

Bibliographic Details
Published in:Bioorganic & medicinal chemistry letters : a Tetrahedron publication for rapid dissemination of preliminary communications on all aspects of bioorganic chemistry, medicinal chemistry, bioinorganic chemistry and related disciplines, Vol. 26, No. 19 (2016), p. 4666-4670
Main Author: Zhang, Ying
Other Involved Persons: Yang, Chao-Rui ; Tang, Xue ; Cao, Sheng-Li ; Ren, Ting-Ting ; Gao, Man ; Liao, Ji ; Xu, Xingzhi
Format: electronic Article
Language:English
ISSN:1464-3405
Physical Description:Online-Ressource
DOI:10.1016/j.bmcl.2016.08.060
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